J Neuroimmunol (Journal of neuroimmunology)Ĭited: 102 times View full text PDF listing > It is possible that these opposing functions might affect the degree of overt suppression during pregnancy and autoimmunity. However, E2 also inhibits the ability of antigen presenting cells (APC) to activate T cells. Magdalena J Polanczyk, Corwyn Hopke, Jianya Huan, Arthur A Vandenbark, Halina Offner,Įstrogen (E2) upregulates the FoxP3 gene that marks regulatory CD4+CD25+ T cells (Treg cells). J Neurosci Res (Journal of neuroscience research)Ĭited: 117 times View full text PDF listing >Įnhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice. We found that E2 treatment in vivo strongly reduced recovery. In this report, we further investigated the effects of E2 on APC and Treg function. Read more >Ĭited: 111 times View full text PDF listing >Įstrogen-mediated immunomodulation involves reduced activation of effector T cells, potentiation of Treg cells, and enhanced expression of the PD-1 costimulatory pathway.Įstrogen (E2)-induced immunomodulation involves dual effects on antigen-presenting cells (APC) and CD4(+)CD25(+) regulatory T cells (Treg) but not a direct effect on effector T cells. To clarify the role of PD-1 versus FoxP3 in E2-enhanced Treg suppression, we evaluated both markers and functional suppression. Recently, Tregs were further characterized by intracellular expression of the negative co-stimulatory molecule, programmed death-1 (PD-1).
Magdalena J Polanczyk, Corwyn Hopke, Arthur A Vandenbark, Halina Offner,Įstrogen is a potent driver of the FoxP3+ regulatory T cell (Treg) compartment. Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1). : 1950))Ĭited: 19 times View full text PDF listing > J Immunol (Journal of immunology (Baltimore, Md. In the current study, we produced a monomeric. We previously demonstrated the therapeutic effects of MHC class II derived recombinant T cell receptor ligands (RTL), single-chain two domain complexes of the alpha1 and beta1 domains of MHC class II molecules genetically linked with an immunodominant peptide, in experimental autoimmune encephalomyelitis. Jianya Huan, Laurie J Kaler, Jeffery L Mooney, Sandhya Subramanian, Corwyn Hopke, Arthur A Vandenbark, Edward F Rosloniec, Gregory G Burrows, Halina Offner,
MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis.